Counterpoint: Because some surrogate end point biomarkers measure the neoplastic process they will have high utility in the development of cancer chemopreventive agents against sporadic cancers.
نویسندگان
چکیده
National Cancer Institute, Division of Cancer Treatment and Diagnosis, Biomedical Imaging Program, Bethesda, Maryland 20892 [G. J. K.]; BaylorSammons Cancer Center, US Oncology, Dallas, Texas 75246 [J. A. O.]; Abbott Laboratories, Abbott Park, IL 60064 [G. B. G.]; National Cancer Institute, Division of Cancer Prevention, Gastrointestinal and Other Cancers Group, Bethesda, Maryland 20892 [E. T. H.]; and CCS Associates, Mountain View, California 94043 [C. C. S.]
منابع مشابه
Can risk assessment and chemoprevention research rely on surrogates for tumour yield?
The main areas of interest within toxicological pathology relevant to cancer prevention are risk assessment, mechanisms of carcinogenesis and chemoprevention. All rely to a large extent on studies in experimental animals. In the present issue of the APJCP, Subapriya and Nagini ( 2003) report on the chemopreventive potential of an ethanol extract of neem leaves in rats, providing evidence of red...
متن کاملPoint: Surrogate end point biomarkers are likely to be limited in their usefulness in the development of cancer chemoprevention agents against sporadic cancers.
Introduction The notion that SEBMs can predict the effectiveness of chemopreventive agents against carcinogenesis in humans has motivated tremendous efforts to development of these compounds (1–3). Successful development of useful SEBMs in AIDS and cardiovascular disease seems to confirm the concept. Why should it not also be valid for chemoprevention of cancer (2)? Unfortunately, oncology has ...
متن کاملCan a marker be a surrogate for development of cancer, and would we know it if it exists?
Carcinogenesis proceeds through a very long preclinical period. Our collective hope is that multiple opportunities exist for chemoprevention to arrest or reverse progression towards malignancy. In the hope of faster progress with fewer subjects and lower total cost, much effort is being expended on the search for reliable biomarkers to predict the likelihood of developing cancer and/or to signa...
متن کاملStrategies for identification and clinical evaluation of promising chemopreventive agents.
Strategies for chemopreventative drug development are based on the use of well-characterized agents, intermediate biomarkers correlating to cancer incidence, and suitable cohorts for efficacy studies. Since chemoprevention is applied over the long-term, chemopreventive drugs must have low toxicity. Strategies for enhancing chemopreventive drug efficacy and minimizing toxicity include combinatio...
متن کاملRole of Molecular Biomarkers in Colorectal Cancer
Colorectal cancer (CRC) is amongst the most widespread cancers and is a most common cause of cancer associated mortality universally. Since previous decades, it has been cleared that CRC develops owing to the buildup of a series of genetic and epigenetic changes in the normal colonic epithelium. Regardless of the current development in surgery and therapies, overall survival of end stage CRC pa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 12 7 شماره
صفحات -
تاریخ انتشار 2003